Checking the Pulse of Vitamin A Metabolism and Signaling during Mammalian Spermatogenesis

Checking the Pulse of Vitamin A Metabolism and Signaling during Mammalian Spermatogenesis

Blog Article

Vitamin A has been shown to be essential for a multitude of biological processes vital for mammalian development and homeostasis.Its active metabolite, retinoic acid (RA), is important for establishing and maintaining proper germ cell development.During spermatogenesis, the germ cells Silver Conductive Paint orient themselves in very distinct patterns, which have been organized into stages.There is evidence to show that, in the mouse, RA is needed for many steps during germ cell development.

Interestingly, RA has been implicated as playing a role within the same two Stages: VII and VIII, where meiosis is initiated and spermiation occurs.The goal of this review is to outline this evidence, exploring the relevant players in retinoid metabolism, storage, transport, and signaling.Finally, this review will provide a potential model for how RA ORG BLACK TURTLE BEANS activity is organized across the murine stages of the spermatogenic cycle.